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IPSA CONGRESS.   
IPSA Congress 2016 - Taiwan March 11-13, 2016
Dear Friends, On behalf of the organizing committee, we are extremely happy to invite you to participate in the
IV International Pediatric Sleep Association Congress (IPSA 2016) which will be held on March 11-13, 2016, in Taipei International Convention Center, located in the heart of Taipei, Taiwan.

We sincerely hope the beauty of our city and the theme of our conference will attract you all. The IPSA 2016 serves as a premier event on the international calendar of pediatric sleep bringing together physicians, educators, basic scientists, sleep technician and clinical investigators from hospitals, industry, and academia to present and share the latest cutting-edge research results and innovative solutions in the related fields. We believe you will have a fruitful and enjoyable time during your stay in Taipei based on our solid program and the hospitality of Taipei, Taiwan aka “Formosa”.(“beautiful in Portuguese”) island, as used by the Portuguese mariners centuries ago to describe Taiwan Look forward to seeing you in Taipei, Taiwan in 2016! Best Regards, Dr. Yu-Shu Huang, Chair of IPSA 2016 and Local Organizer Dr. Daniel KK Ng, Co-Chair of IPSA 2016 Dr. Oliviero Bruni, President of IPSA Dr. Chia-Mo Lin, President of Taiwan Society of Sleep Medicine   read more...

IPSA Congress 2014 - Porto Alegre - Brazil - Sunday, September 29, 2013

It is my pleasure to present the
III Congress of the International Pediatric Sleep Association (IPSA) - Porto Alegre (Brazil) 3-5 December 2014.

The importance of sleep for health, learning and psychomotor development in infancy, childhood and adolescence has been emphasized in the pediatric research in the last two decades and it has become more and more evident that ensuring a good sleep during development is of key importance for a later healthy life.
The IPSA Congress is an influential forum for sleep practitioners from around the world to network and exchange views, whilst learning from world-class researchers about the latest scientific and clinical developments in the field.
The success of the last two Congresses in Rome 2010 and Manchester 2012 has highlighted the magnitude of Pediatric Sleep Medicine in the scientific community and we hope that the 2014 Congress will provide a perfect balance between didactic and practical needs, in order to provide the technical knowhow and up-to-date knowledge that will enable participants to improve their practice.
As traditional for IPSA, the most renowned International opinion leaders in the field of Pediatric Sleep Medicine speakers will join the Congress and will highlight the recent significant advances in both basic science and clinical sleep medicine during development.
I hope that the world paediatric sleep community will gather together in the lively city of Porto Alegre to celebrate the best clinical practice and the latest advances in Pediatric Sleep Medicine.

Oliviero Bruni
President of the International Pediatric Sleep Association

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IPSA Congress 5-7 december 2012 - Manchester City (UK)

IPSA Congress 5-7th December 2012 - Manchester (UK)   read more...

ABSTRACT BOOK OF THE IPSA CONGRESS, Rome 3-5 December 2010

IPSA 2010 - Abstract Book

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 Announcements

Guia SAOS Infantil Espanola

New guidelines on the diagnosis and treatment of OSA in children published by the Spanish Pediatric Sleep Group. (available only in Spanish)

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RECENT LITERATURE HIGHLIGHTS   
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Sleep Behaviors and Sleep Problems in School-Aged Children in Thailand.
Related Articles

Sleep Behaviors and Sleep Problems in School-Aged Children in Thailand.

J Med Assoc Thai. 2015 Oct;98 Suppl 9:S71-7

Authors: Sirirassamee F, Chonchaiya W, Pruksananonda C

Abstract
BACKGROUND: Sleep problems can have a significant effect on children behaviors, emotional and cognitive developments. However, limited information is available regarding the sleep behaviors and sleep problems of school-aged children in Thailand. The purposes of this study were to examine the prevalence of sleep problems and to describe sleep/wake pattern of Thai children.
MATERIAL AND METHOD: The school-based, cross-sectional study was conducted in 5 primary public schools selected from Bangkok and three regions of Thailand. The samples were selected from the first and fourth grades of each school. The Children's Sleep Habits Questionnaire (CSHQ) was used to evaluate sleep behaviors and sleep problems.
RESULTS: Grade 1 children went to bed earlier and had longer weekday sleep duration comparing with grade 4 children. Sleep duration was significantly shorter in children living in Bangkok, comparing with those living in rural areas. Mean total CSHQ score was significant higher in grade 1 children, when comparing with grade 4 children (51.30 vs. 50.18; p = 0.026). Grade 1 children scored significantly higher on bedtime resistance (10.96 vs. 10.39; p = 0.004) and sleep anxiety subscale (6.68 vs. 6.41; p = 0.022), while grade 4 children scored significantly higher on sleep-onset delay subscale (1.41 vs. 1.23; p < 0.001). Prevalence of sleep problems was highest in the category of "falling asleep while riding in car or bus" (69.5%), followed by "awakening by others in the morning" (68.5%).
CONCLUSION: Sleep problems were common in Thai school-aged children. The most common sleep problems were in the domains of daytime sleepiness and bedtime resistance and anxiety.

PMID: 26817213 [PubMed - indexed for MEDLINE]


Severe Central Sleep Apnea in Vici Syndrome.
Related Articles

Severe Central Sleep Apnea in Vici Syndrome.

Pediatrics. 2015 Nov;136(5):e1390-4

Authors: El-Kersh K, Jungbluth H, Gringras P, Senthilvel E

Abstract
Vici syndrome is a rare congenital multisystem disorder due to recessive mutations in the key autophagy regulator EPG5. Vici syndrome is characterized by agenesis of the corpus callosum, hypopigmentation, immunodeficiency, cataracts, and cardiomyopathy, with variable additional multisystem involvement. Here we report on a 5-year-old girl who presented with global developmental delay, seizures, callosal agenesis, cataracts, sensorineural hearing loss, hypopigmentation, and immunodeficiency with a low CD4 count and recurrent infections. EPG5 sequencing (prompted by suggestive clinical features) revealed a homozygous missense mutation, c.1007A>G (p.Gln336Arg). The patient was referred to our center for evaluation of nocturnal apnea. Overnight polysomnography showed severe central sleep apnea (CSA) with an overall apnea-hypopnea index of 100.5 events per hour of sleep (central apnea index of 97.5, mixed apnea index of 2, and obstructive hypopnea index of 1). The patient responded to bilevel positive airway pressure therapy with a backup rate with normalization of the apnea-hypopnea index and maintenance of oxygen saturation >90%. Despite successful control of the severe CSA, the patient was eventually started on nocturnal oxygen therapy due to excessive upper airway secretions and the high risk of possible aspiration with positive airway pressure therapy. This is the first report of EPG5-related Vici syndrome associated with CSA. We discuss the polysomnographic findings in our patient in the context of a brief literature review of the reported sleep abnormalities in Vici syndrome.

PMID: 26482670 [PubMed - indexed for MEDLINE]


Polysomnographic Markers in Children With Cystic Fibrosis Lung Disease.
Related Articles

Polysomnographic Markers in Children With Cystic Fibrosis Lung Disease.

Pediatrics. 2015 Nov;136(5):920-6

Authors: Paranjape SM, McGinley BM, Braun AT, Schneider H

Abstract
BACKGROUND AND OBJECTIVES: Children with cystic fibrosis (CF) often report poor sleep, increased daytime sleepiness, and fatigue. The purpose of this study was to identify respiratory patterns over the spectrum of disease severity in children with CF. The overall hypothesis for the current study is that children with CF compared with snoring control subjects demonstrate gas exchange abnormalities and increased respiratory loads during sleep that are not reported or recognized by conventional polysomnography (PSG).
METHODS: Analysis of breathing patterns and gas exchange on PSG was performed in children with CF and healthy controls matched by age and BMI. For all CF and control subjects, the indication for PSG was evaluation for obstructive sleep apnea based on a history of snoring.
RESULTS: Children with CF, compared with age- and BMI-matched snoring controls, demonstrated lower oxyhemoglobin saturation (95% ± 1.6% vs 98% ± 0.6%, P = .005), higher respiratory rate (19.5 ± 4.9 vs 16.5 ± 1.2 breaths per minute, P = .03), and a higher proportion of inspiratory flow limitation (44.1% ± 24.7% vs 12.1% ± 13.5%, P = .007) during non-rapid eye movement sleep. The respiratory disturbance index did not differ between CF and snoring control groups (1.5 ± 2.7 vs 0.6 ± 0.6 events per hour, P = .11).
CONCLUSIONS: Children with CF exhibited abnormalities in gas exchange and increased respiratory load during sleep compared with normal age- and BMI-matched snoring controls. Because these abnormalities were independent of weight and lung function, sleep state may serve as an opportunity for early detection of breathing abnormalities and possibly CF lung disease progression.

PMID: 26482667 [PubMed - indexed for MEDLINE]


Outcome following multiple subpial transection in Landau-Kleffner syndrome and related regression.
Related Articles

Outcome following multiple subpial transection in Landau-Kleffner syndrome and related regression.

Epilepsia. 2015 Nov;56(11):1760-6

Authors: Downes M, Greenaway R, Clark M, Helen Cross J, Jolleff N, Harkness W, Kaliakatsos M, Boyd S, White S, Neville BG

Abstract
OBJECTIVE: To determine whether multiple subpial transection in the posterior temporal lobe has an impact on long-term outcome in children who have drug-resistant Landau-Kleffner syndrome (LKS) or other "electrical status epilepticus during sleep" (ESES)-related regression. Given the wide variability in outcomes reported in the literature, a secondary aim was to explore predictors of outcome.
METHODS: The current study includes a surgery group (n = 14) comprising patients who underwent multiple subpial transection of the posterior temporal lobe and a nonsurgery comparison group (n = 21) comprising patients who underwent presurgical investigations for the procedure, but who did not undergo surgery. Outcomes were assessed utilizing clinical note review as well as direct assessment and questionnaires.
RESULTS: The distribution of nonclassical cases was comparable between groups. There were some differences between the surgery and nonsurgery groups at presurgical investigation including laterality of discharges, level of language impairment, and age; therefore, follow-up analyses focused on change over time and predictors of outcome. There were no statistically significant differences between the groups in language, nonverbal ability, adaptive behavior, or quality of life at follow-up. There was no difference in the proportion of patients showing improvement or deterioration in language category over time for either group. Continuing seizures and an earlier age of onset were most predictive of poorer quality of life at long-term follow-up (F2,23 = 26.2, p = <0.001, R(2) = 0.714).
SIGNIFICANCE: Both surgery and nonsurgery groups had similar proportions of classic LKS and ESES-related regression. Because no significant differences were found in the changes observed from baseline to follow-up between the two groups, it is argued that there is insufficient evidence to suggest that multiple subpial transection provides additional benefits over and above the mixed recovery often seen in LKS and related regressive epilepsies.

PMID: 26337264 [PubMed - indexed for MEDLINE]


Referral Patterns and Positive Airway Pressure Adherence upon Diagnosis of Obstructive Sleep Apnea.
Related Articles

Referral Patterns and Positive Airway Pressure Adherence upon Diagnosis of Obstructive Sleep Apnea.

Otolaryngol Head Neck Surg. 2015 Nov;153(5):881-7

Authors: Russell JO, Gales J, Bae C, Kominsky A

Abstract
OBJECTIVE: Obstructive sleep apnea (OSA) is a serious medical condition that adds to patient morbidity and mortality. Treatment with positive airway pressure (PAP) is the standard of care, but many patients refuse or do not tolerate PAP. Little is known about the subsequent management of these patients. We sought to understand what types of treatment, if any, adult patients with OSA receive who either fail or refuse PAP therapy within our institution.
STUDY DESIGN: Retrospective chart review.
SETTING: Academic hospital.
SUBJECTS: All adult patients undergoing polysomnogram during the months of March and April 2010 (n = 1174) who were diagnosed with OSA.
METHODS: The electronic medical record was reviewed to determine the subsequent management of patients with a diagnosis of OSA, including tolerance or failure of PAP and referral to specialists upon intolerance.
RESULTS: Of 1174 patients, 616 met inclusion criteria. Ultimately, 260 (42%) had documented adherence to PAP. Of 241 untreated patients, 84 patients (35%) were referred for further attempts at management of diagnosed OSA. Nearly half of patients with diagnosed OSA did not have continued treatment or referral.
CONCLUSION: To our knowledge, this is the first study to define the subsequent management of patients who have failed or refused PAP. Despite the known sequelae of OSA, clinicians are not treating a significant percentage of patients with diagnosed OSA. Those who fail to tolerate PAP therapy are unlikely to be referred for additional treatment. Therapies other than PAP may be warranted in this population.

PMID: 26209076 [PubMed - indexed for MEDLINE]


Evidence of Placental Hypoxia in Maternal Sleep Disordered Breathing.
Related Articles

Evidence of Placental Hypoxia in Maternal Sleep Disordered Breathing.

Pediatr Dev Pathol. 2015 Sep-Oct;18(5):380-6

Authors: Ravishankar S, Bourjeily G, Lambert-Messerlian G, He M, De Paepe ME, Gündoğan F

Abstract
Sleep disordered breathing (SDB) represents a spectrum of disorders, including habitual snoring and obstructive sleep apnea (OSA). Sleep disordered breathing is characterized by chronic intermittent hypoxia, airflow limitation, and recurrent arousals, which may lead to tissue hypoperfusion, hypoxia, and inflammation. In this study, we aimed to examine whether SDB during pregnancy was associated with histopathologic evidence of chronic placental hypoxia and/or uteroplacental underperfusion. The placentas of women with OSA (n  =  23) and habitual snoring (n  =  78) as well as nonsnorer controls (n  =  47) were assessed for histopathologic and immunohistochemical markers of chronic hypoxia and uteroplacental underperfusion. Fetal normoblastemia was significantly more prevalent in SDB placentas than in those of nonsnorer controls (34.6% and 56.5% in snorers and OSA, respectively, versus 6.4% in controls). Expression of the tissue hypoxia marker carbonic anhydrase IX (CAIX) was more common in OSA placentas than controls (81.5% and 91.3% in snorers and OSA, respectively, versus 57.5% in controls). Adjusting for confounders such as body mass index, diabetes mellitus, or chronic hypertension did not alter the results. The uteroplacental underperfusion scores were similar among the 3 groups. Our findings suggest that SDB during pregnancy is associated with fetoplacental hypoxia, as manifested by fetal normoblastemia and increased placental carbonic anhydrase IX immunoreactivity. The clinical implications and underlying mechanisms remain to be determined.

PMID: 26186234 [PubMed - indexed for MEDLINE]

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